论文部分内容阅读
目的调查我省一般人群尿液中多环芳烃单羟基代谢产物2-羟基萘、1-羟基萘、3-羟基菲和1-羟基芘的水平,为进一步的研究工作提供基线资料。方法 2009—2010年在辽宁省东部、中部和西部的3个城市,采用随机抽样的方法选取764名6~60岁人群,对其生活环境和健康状况进行问卷调查并收集尿液样品;采用液相色谱质谱联用仪检测764份尿液中2-羟基萘、1-羟基萘、3-羟基菲和1-羟基芘的水平,统计分析不同性别和年龄人群尿中代谢产物的分布情况。结果我省一般人群尿中1-羟基萘、2-羟基萘、3-羟基菲和1-羟基芘的几何均数(95%CI)分别为1.86(1.72~2.04)、1.85(1.58~2.16)、0.66(0.60~0.71)、0.77(0.69~0.86)μg/L,中位数分别为0.95、2.98、0.73和0.83μg/L。2-羟基萘、3-羟基菲和1-羟基芘含量在男性和女性间差异有统计学意义;1-羟基萘、2-羟基萘和1-羟基芘在不同年龄组间含量差异均有统计学意义;4种代谢物含量在我省东、中、西部间存在差异;吸烟与否在1-羟基萘、2-羟基萘、3-羟基菲含量中差异有统计学意义。结论辽宁省一般人群尿中多环芳烃单羟基代谢物的水平存在性别、年龄、地区差异,本研究为进一步开展多环芳烃代谢产物生物监测提供了基础。
Objective To investigate the levels of 2-hydroxynaphthalene, 1-hydroxynaphthalene, 3-hydroxy-phenanthrene and 1-hydroxypyrene in the urine of polycyclic aromatic hydrocarbons (PAHs) in the general population in our province, so as to provide baseline data for further research. Methods From July 2010 to 2010, 764 people aged 6-60 years were selected randomly in three cities of eastern, central and western Liaoning Province to survey their living environment and health status and collect urine samples. The levels of 2-hydroxynaphthalene, 1-hydroxynaphthalene, 3-hydroxy-phenanthrene and 1-hydroxypyrene in 764 urine samples were detected by GC-MS, and the distribution of urinary metabolites in different gender and age groups was statistically analyzed. Results The geometric mean (95% CI) of urinary 1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxy-phenanthrene and 1-hydroxypyrene were 1.86 (1.72-2.04), 1.85 (1.58-2.16) , 0.66 (0.60 ~ 0.71) and 0.77 (0.69 ~ 0.86) μg / L, respectively. The median were 0.95, 2.98, 0.73 and 0.83 μg / L, respectively. The contents of 2-hydroxynaphthalene, 3-hydroxy-phenanthrene and 1-hydroxypyrene in male and female were statistically significant. The differences of contents of 1-hydroxynaphthalene, 2-hydroxynaphthalene and 1-hydroxypyrene in different age groups were statistically significant The significance of the four metabolites in the eastern, central and western regions of China was statistically significant. Smoking or not had significant differences among the contents of 1-hydroxynaphthalene, 2-hydroxynaphthalene and 3-hydroxy-phenanthrene. Conclusions There is a gender, age and regional difference in urinary levels of monohydroxy metabolites of PAHs in the general population in Liaoning Province. This study provides the basis for further biological monitoring of PAHs metabolites.