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目的研究双水平呼吸道正压通气治疗慢性阻塞性肺疾病(COPD)伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)重叠综合征的临床效果。方法将60例COPD、OSAHS重叠综合征患者随机分为对照组和实验组,每组30例,对照组行持续正压通气治疗,实验组行双水平呼吸道正压通气治疗。比较两组患者的治疗效果。结果治疗后对照组患者动脉氧分压(Pa O2)、脉搏氧饱和度(Sp O2)及p H值均低于实验组,动脉二氧化碳分压(Pa CO2)水平高于实验组,差异有统计学意义(P<0.05);且治疗后对照组呼吸暂停低通气指数(AHI)、最长呼吸暂停时间、C-反应蛋白(CRP)水平、肿瘤坏死因子-α(TNF-α)水平均高于实验组,差异有统计学意义(P<0.05)。结论给予COPD、OSAHS重叠综合征患者双水平呼吸道正压通气疗效显著,可改善患者肺部通气、睡眠呼吸效果,提高患者生活质量。
Objective To study the clinical effect of biphasic positive airway pressure ventilation in treating obstructive sleep apnea-hypopnea syndrome (OSAHS) overlap syndrome in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty patients with COPD and OSAHS overlap syndrome were randomly divided into control group and experimental group, with 30 cases in each group. The control group received continuous positive pressure ventilation and the experimental group received double-level positive airway pressure ventilation. The treatment effect of two groups of patients was compared. Results The PaO2, Sp O2 and p H of the control group were lower than those of the experimental group after treatment, and the PaCO 2 of the artery was higher than that of the experimental group (P <0.05). After the treatment, the AHI, longest apnea time, C-reactive protein (CRP) level and tumor necrosis factor-α (TNF-α) In the experimental group, the difference was statistically significant (P <0.05). Conclusion COPD and OSAHS overlap syndrome patients with double-level positive airway pressure ventilation have significant curative effect, which can improve lung ventilation and sleep respiration of patients and improve the quality of life of patients.