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目的:探讨清音片长期给药对大鼠血液生化指标的影响,对其安全性作出评价。方法:长期毒性试验将动物分为对照组和清音丸高剂量组,清音片高、中、低剂量组,给药剂量为临床用药量的120、60、30倍,经口灌胃给药。连续重复给药后及停药后观察动物一般表现,测定血液学、血液生化学指标。结果:长毒试验观察动物无1例死亡,外观体征和行为无异常改变;血液学和血液生化学指标与对照组比较无显著性差异。结论:清音片无明显长期毒性反应,在临床剂量下使用是安全的。
Objective: To investigate the effect of long-term administration of Qingyin tablets on blood biochemical parameters in rats and to evaluate its safety. Methods: Long-term toxicity test animals were divided into control group and high-dose group of Qingyin pill, high-dose, medium-dose and low-dose group. The dosage was 120, 60, 30 times of the clinical dosage. Continuous repeated administration and observation of animals after stopping the general performance, determination of hematology, blood biochemical indicators. Results: There were no deaths and no abnormal changes of appearance signs and behaviors in long-poisoned animals. There was no significant difference between hematology and blood biochemical indexes in control group. Conclusion: There is no obvious long-term toxic reaction, and it is safe to use in clinical dosage.