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目的:探讨采用阿德福韦酯联合拉米夫定药物治疗乙肝肝硬化患者的临床治疗效果。方法:选取2012年8月~2014年9月在本院接受治疗的90例乙肝肝硬化疾病患者作为研究对象,按数字列表法将其随机分为研究组和对比组,每组各45例。对照组患者给予拉米夫定药物治疗,研究组在对照组的基础上再联合阿德福韦酯药物治疗,对比两组患者治疗情况。结果:研究组患者经过药物治疗后,其治疗所用时间为(75.3±10.5)d,HBV转阴用时为(53.8±7.5)d,转阴率高达39例(86.67%),此外在治疗效果方面,其治疗的有效率高达91.11%;对比组病人经药物治疗后,其治疗所用时间为(95.6±15.8)d,HBV转阴用时为(81.3±11.6)d,转阴率达到28例(62.22%),此外在治疗效果方面,其治疗的有效率高达62.22%。研究组病人在以上方面都要明显优于对比组患者,存在显著差异,具有统计学意义(P<0.05)。结论:在乙肝肝硬化疾病的临床治疗中,采用拉米夫定药物治疗,同时加阿德福韦酯药物进行治疗,具有良好的治疗效果,能够极大的提升治疗的有效率,极大的缩短病人的治疗时间,同时还能有效的提升HBV的转阴率,及缩短其转阴用时,因而该药物治疗方法在该疾病的临床治疗中,有着积极的推广价值。
Objective: To investigate the clinical effect of adefovir dipivoxil combined with lamivudine in the treatment of hepatitis B cirrhosis. METHODS: Ninety patients with hepatitis B cirrhosis who were treated in our hospital from August 2012 to September 2014 were selected as study subjects. They were randomly divided into study group and control group according to digital list method, with 45 cases in each group. Patients in the control group were treated with lamivudine. The study group was treated with adefovir dipivoxil on the basis of the control group, and the treatment was compared between the two groups. Results: After treatment, the study group took (75.3 ± 10.5) days of treatment, (53.8 ± 7.5) days of HBV negative conversion and 39 cases (86.67%) of negative conversion rate. In addition, in the treatment effect , The effective rate of treatment was as high as 91.11%. The treatment time of the patients in the control group was (95.6 ± 15.8) d, the time of HBV-negative conversion was (81.3 ± 11.6) days and the rate of negative conversion reached 28 (62.22 %), In addition to the treatment effect, the effective treatment rate of up to 62.22%. The study group of patients in the above aspects were significantly better than the control group of patients, there were significant differences, with statistical significance (P <0.05). Conclusion: In the clinical treatment of hepatitis B cirrhosis, the use of lamivudine drug treatment, while adefovir dipivoxil treatment, has a good therapeutic effect, can greatly improve the efficiency of treatment, great Shorten the patient’s treatment time, but also can effectively improve the rate of HBV negative conversion, and shorten its negative conversion time, so the drug treatment in the clinical treatment of the disease, has a positive promotional value.