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目的探讨复方甲氧那明胶囊对咳嗽变异性哮喘(cough variantasthm a,CVA)患者肺功能和临床疗效的影响。方法134例CVA患者随机分为两组,A组(67例)口服复方甲氧那明胶囊,每日3次,每次2粒;B组(67例)吸入丙酸氟的卡松(FP)125μg每日早晚各1次。两组均治疗12周。观察临床症状及肺功能的变化。结果A组治疗后第2周临床症状、晨间最大呼气峰流速值(PEFam)、晚间最大呼气峰流速值(PEFpm)及FEV1%等指标即好转,治疗后的第4,8,12周上述指标同治疗前相比差异均有显著性(P<0.05);B组治疗前后上述指标比较亦有显著性差异(P<0.05);A组和B组比较无显著性差异(P>0.05)。结论口服复方甲氧那明胶囊对CVA患者有改善肺功能和降低非特异性气道高反应性的作用。
Objective To investigate the effect of compound metoprolol on pulmonary function and clinical efficacy in patients with cough variant asthma (CVA). Methods One hundred and thirty-four patients with CVA were randomly divided into two groups. Group A (67 patients) took omeprazole capsules orally three times a day for 2 capsules. In group B, 67 125μg daily morning and evening 1 times. Both groups were treated for 12 weeks. Observation of clinical symptoms and changes in lung function. Results The clinical symptoms, peak morning expiratory flow rate (PEFam), night maximum expiratory peak flow velocity (PEFpm) and FEV1% of group A improved after treatment. After treatment, There were significant differences between the above indexes before treatment and those before treatment (P <0.05); there was significant difference between the two groups before and after treatment (P <0.05); there was no significant difference between group A and group B (P> 0.05). Conclusion Oral compound metoprolol can improve lung function and reduce nonspecific airway hyperresponsiveness in CVA patients.