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Crohn病(下称CD)是一种炎症性肠病。1932年由Crohn氏首先描述,1973年由世界卫生组织(WHO)正式命名。目前多认为CD的发病机制是抗体依赖性细胞介导性细胞毒(ADCC)侵害肠粘膜所致,表现为肠道非连续性的区域性病变,特征是非干酪样上皮细胞肉芽肿。CD时肠外表现如神经、皮肤、眼、口腔、心肺、血管、肝肾、骨关节、骨髓等多脏器均可受累,出现多系统临床表现,近年来已为人们所重视。CD在我国并非罕见,截至1984年止,文献报告已达634例,实际病例可能更多些。本文就CD治疗现状与展望作一介绍。
Crohn’s disease (CD) is an inflammatory bowel disease. Crohn’s first description in 1932, 1973 by the World Health Organization (WHO) officially named. At present, many believe that the pathogenesis of CD is caused by antibody-dependent cell-mediated cytotoxicity (ADCC) invasion of the intestinal mucosa, presenting as a regional lesion of intestinal non-continuity characterized by non-caseous-like epithelial granulomas. CD when parenteral manifestations such as nerves, skin, eyes, mouth, heart and lungs, blood vessels, liver and kidney, bone and joint, bone marrow and other multiple organs can be involved, the emergence of multi-system clinical manifestations in recent years has been valued. CD is not uncommon in our country. As of 1984, the number of reported cases has reached 634, the actual cases may be more. This article on the status of CD treatment and prospects for an introduction.