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本综合症最先由川崎富作于1962年以《非猩红热性脱屑症候群》为题报告7例。5年后,该作者又以《伴有指趾特异脱屑的小儿急性热性皮肤粘膜淋巴结症候群》为题,报告50例。本综合症做为儿科新的疾病,引起了世界学者、临床医师的注意。1970年日本成立了研究班,对本病确定了诊断标准,进行了调查。至1976年全日本已有10,000例以上。其它国家也有报告。目前,本综合症已被多数学者所确认,称为《急性热性皮肤粘膜淋巴结综合症》(英文缩写MCLS,美国缩写为MLNS)。因为川崎氏首先发现本病,在日本亦称为《川崎病》。本文仅就该综合症的临床、病理、及病因探讨等诸方面综述如下。
The syndrome was first reported by Kawasaki Tomio in 1962 as “non-scarlet fever scaling syndrome” in the title report of seven cases. Five years later, the author again reported “50 cases of pediatric acute hot cutaneous mucosal lymphadenopathy syndrome with finger-specific desquamation.” The syndrome as a new pediatric disease, attracted the attention of scholars and clinicians in the world. In 1970 Japan set up a research class to determine the diagnostic criteria for the disease, conducted a survey. By 1976 there were over 10,000 cases in Japan. Other countries have also reported. At present, the syndrome has been recognized by most scholars, known as “acute thermal cutaneous mucosa lymph node syndrome” (abbreviation MCLS, the United States abbreviated as MLNS). Because Kawasaki first discovered the disease, also known in Japan as “Kawasaki disease.” This article only on the syndrome of clinical, pathological, and etiology and other aspects are summarized below.