论文部分内容阅读
目的：对比分析不同剂量的他汀治疗在非 ST 段抬高的急性冠脉综合征患者中的安全性。方法入选欲行冠状动脉造影检查及经皮冠状动脉介入治疗（PCI）的非 ST 段抬高的急性冠脉综合征（ACS）患者15例，随机分为强化治疗组（7例）和常规治疗组（8例）。强化治疗组：PCI 术前给予阿托伐他汀80 mg/ d，连用2 d，术后阿托伐他汀40 mg/ d，直至术后30 d，此后阿托伐他汀20 mg/ d 维持治疗；常规治疗组一开始即给予阿托伐他汀10~20 mg，每晚睡前口服，分别于 PCI 术前、术后第2天、术后（30±3）d、术后（90±7）d、术后（180±7）d 等时间点采血查丙氨酸氨基转移酶（ALT）、总胆红素（TBiL）、肌酐（Cr）（术后90、180 d 未查）、肌酸激酶（CK）。结果强化治疗组只有术后30 d 的 TBiL 值较常规治疗组明显增高，但是呈一过性。其余指标在各个时间点两组间比较差异均无统计学意义（P >0.05）。结论介入治疗术前强化他汀治疗在非 ST 段抬高的急性冠脉综合征患者中是安全的。“,”Objective To analyze the security of different doses statins treatment before PCI in patients with non ST elevation acute coronary syndrome. Methods Fifteen patients with non-ST-elevation acute coronary artery diseases scheduled for PCI were selected. These patients were randomly divided into two groups:intensive treatment group(7 cases)and conventional treatment group(8 cases). Patients in intensive treatment group were given atorvastatin 80 mg/ d for 2 days before PCI,then 40 mg/ d for 30 days after PCI,then 20 mg/ d for long. Patients in conventional treatment group were given atorvastatin 10 - 20 mg orally,ev-ery night,from start to finish. For the two groups,before PCI,and 2 d,(30 ± 3)d,(90 ± 7)d,(80 ± 7)d after PCI,the ser-um level of ALT,TBiL,Cr(except 90,180 days after PCI),CK were detected. Results Only TBiL of 30 days after PCI in in-tensive statins treatment group was higher than that in convenional treatment group(P = 0. 002),but it was transient. There were no significant differences in other indexes at any time points between the two groups(P > 0. 05). Conclusion Intensive statins treatment before PCI in patients with non-ST-elevation acute coronary syndrome is secure.