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背景:初步研究提示,冠状动脉内移植骨髓(BMC)源性或循环血(CPC)源性祖细胞可改善急性心肌梗死后的左室功能。细胞移植对心肌梗死已治愈患者有何效果尚不知晓。方法:在包括17例患者的最初试验后,在一项对照交叉研究中随机分配75例有既往心肌梗死病史(至少已3个月)的稳定性缺血性心脏病患者接受无细胞注射治疗(23例患者)抑或CPC(24例患者)或BMC(28例患者)注射入供应左室运动障碍最严重区域的开放冠状动脉。
BACKGROUND: Preliminary studies suggest that intracoronary transplantation of bone marrow (BMC) -derived or circulating blood (CPC) -cerebral progenitor cells may improve left ventricular function after acute myocardial infarction. The effect of cell transplantation on patients who have been cured of myocardial infarction is unknown. METHODS: After the initial trial consisting of 17 patients, 75 patients with stable ischemic heart disease randomized to a history of previous myocardial infarction (at least 3 months) in a controlled cross-over study were treated with cell-free injections 23 patients) or CPC (24 patients) or BMC (28 patients) were injected into open coronary arteries supplying the most severely left ventricular dysfunction.