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目的 :探讨前列腺增生间质结节的演化过程 ,进一步认识前列腺增生病理组织学分类依据。方法 :应用免疫组织化学方法对 5 5个前列腺增生的间质结节做了波形蛋白、肌细胞肌动蛋白、平滑肌肌动蛋白和第Ⅷ因子相关抗原的免疫组化染色。结果 :结合HE切片和免疫组化结果发现前列腺间质结节的早期为幼稚的纤维性结节 ,随着结节内肌纤维母细胞向平滑肌细胞和纤维细胞的双向分化 ,间质结节可继续演化为纤维肌性结节和肌性结节。5 5个结节按免疫组化分类 ,纤维性结节占 42 % ,纤维肌性结节占 5 1% ,肌性结节占 7%。结论 :前列腺早期的纤维性结节随着肌纤维母细胞向平滑肌和纤维细胞的分化而演化为纤维肌性结节和肌性结节 ,明确这种演化过程可进而认识前列腺增生的病理学分类
Objective: To explore the process of prostatic hyperplasia interstitial nodules, to further understand the histopathological basis of benign prostatic hyperplasia. Methods: Immunohistochemical staining was used to detect the expression of vimentin, myocyte actin, smooth muscle actin, and factor Ⅷ related proteins in 55 benign prostatic hyperplasia stromal nodules. Results: Combined with HE section and immunohistochemistry results, it was found that the prostatic stromal nodules were immature fibrous nodules in the early stage. As the myenteric myofibroblasts differentiated into smooth muscle cells and fibroblasts, interstitial nodules could continue Evolved into fibromuscular and muscular nodules. Fifty-five nodules were classified by immunohistochemistry, with fibrous nodules accounting for 42%, fibromuscular nodules accounting for 51% and muscle nodules accounting for 7%. CONCLUSION: Early fibrotic nodules of the prostate evolve into fibromuscular nodules and muscular nodules with the differentiation of myofibroblasts to smooth muscle and fibroblasts. It is clear that this evolutionary process can then identify the pathological classification of benign prostatic hyperplasia