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本研究应用发色底物法（ＣＳ）测定了两类原发性头痛：偏头痛及紧张性头痛患者血浆组织型纤溶酶原激活物（ｔ－ＰＡ）及其快速抑制物（ＰＡＩ－１）活性的变化规律。结果发现：两类原发性头痛患者血浆ｔ－ＰＡ活性变化不明显，而ＰＡＩ－１ 活性均明显增高，说明两类原发性头痛患者均存在血管内皮功能损伤及血浆纤溶活性的异常。原发性头痛者中存在着缺血性ＣＶＤ的高危个体，临床医师应对其引起重视，及时给予针对性治疗，以防止脑梗塞的发生。
In this study, two kinds of primary headache were determined by chromogenic substrate method (CS): plasma tissue-type plasminogen activator (t-PA) and its rapid inhibitor (PAI-1 ) Activity changes. The results showed that there was no obvious change of plasma t-PA activity and PAI-1 activity in two kinds of patients with primary headache, which indicated that endothelial dysfunction and plasma fibrinolytic activity were abnormal in both types of primary headache patients. Primary headache, there is a high risk of ischemic CVD individuals, clinicians should pay attention to it, timely and targeted treatment to prevent the occurrence of cerebral infarction.