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目的:通过检测肠道病毒71型手足口病(HFMD)患儿血清中轻链κ、轻链λ和κ/λ比值的变化,探讨血清轻链检测在手足口病诊断中的意义。方法:对178例EV71感染的手足口病患儿和40例健康体检儿童的血清标本进行轻链κ、轻链λ及κ/λ比值检测,并对其结果进行统计学分析。结果:HFMD组血清轻链κ水平显著低于健康组(P<0.05),差异有统计学意义;HFMD组血清轻链λ水平及κ/λ比值与健康组比较有所降低,但差异无统计学意义(P>0.05)。HFMD组血清轻链κ、λ及κ/λ比值异常率均显著高于健康组(P<0.05),差异有统计学意义。结论:EV71感染的手足口病患儿的轻链结果有显著变化,提示EV71感染的手足口病患儿存在体液免疫的紊乱。
Objective: To explore the significance of serum light chain detection in the diagnosis of hand-foot-mouth disease by detecting the changes of light chain κ, light chain λ and κ / λ ratio in serum of children with enterovirus 71 type HFMD. Methods: The light chain κ, light chain λ and κ / λ ratio of 178 EV71 children with hand-foot-mouth disease and 40 healthy children were detected. The results were statistically analyzed. Results: The level of serum light chain κ in HFMD group was significantly lower than that in healthy group (P <0.05), and the difference was statistically significant. The levels of λ and κ / λ in HFMD group were lower than those in healthy group, but the difference was not statistically significant Significance (P> 0.05). HFMD group, the serum light chain κ, λ and κ / λ ratio abnormalities were significantly higher than the healthy group (P <0.05), the difference was statistically significant. Conclusion: The results of light chain changes in children with hand-foot-mouth disease (EV71) have significant changes, suggesting that humoral immune disorder exists in children with hand-foot-mouth disease with EV71 infection.