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目的了解云南地区部分HIV感染患者口腔内牙周致病菌检出情况。方法采用临床标本收集的方法，获得昆明市第三人民医院感染一科66例HIV感染者的唾液标本和龈沟液标本，通过DNA的提取和PCR检测，对标本中的6种牙周致病菌进行检测并运用统计学方法分析。结果不同细菌在不同取材标本都有检出，且各种细菌的检出率差异很大，但同一细菌在不同样本中检出率差异却极小。另外，吸烟饮酒、不同CD4细胞计数和高效抗逆转录病毒治疗(highly active anti retrovial therapy，HAART)HAART对可疑牙周致病菌的检出均无明显影响。结论应结合国内外的研究与报道，加强对HIV感染者口腔牙周致病菌的研究与检测，从而有针对性的治疗发生在HIV感染者口腔中的牙周疾病。“,”Objective To understand the detection of oral periodontal pathogens in part of HIV infected patients in Yunnan region.Methods The col ection of clinic specimens were took to obtain the 66 cases of HIV infected patients,saliva and gingival crevicular fluid (GCF)samples which were come from the Third People,s of Kunming.The six kinds of periodontal pathogens were detected by extraction of DNA and PCR testing and analyzed by using statistical methods.Results The dif erent bacteria have been detected in dif erent specimens and the discrepancy of detection rate of these bacteria was significant.However,the dif erence of same bacterial in dif erent samples was minimal.In addition,there was no manifest function on the detection rate of periodontal pathogens in aspects of smoking,drinking,dif erent CD4 cel counts and highly active antiretroviral therapy(HAART).Conclusion It is vital to strengthen the research and detection of oral periodontal pathogens in HIV infected patients through combine with domestic and international research and report to treat targeted periodontal disease that occur ed in HIV infected patients.