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目的:探讨小柴胡汤辅助化疗对晚期肺癌患者炎性因子与免疫功能的影响。方法:选择2012年5月—2014年11月间接受住院治疗的晚期肺癌患者112例为研究对象,采用随机数字表法分为观察组及对照组各56例。对照组患者接受单纯化疗,观察组患者接受小柴胡汤辅助化疗,比较两组炎性因子、免疫功能、治疗效果、不良反应。结果:近期疗效:观察组有效率、疾病控制率均明显高于对照组(46.43%vs 23.21%,78.57%vs60.71%)(χ2=4.223~6.648,P<0.05);炎性因子:观察组患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平低于对照组患者(t=14.101~17.437,P<0.05);免疫功能:观察组CD4+、CD4+/CD8+水平明显高于对照组,CD8+水平明显低于对照组(t=3.185~7.007,P<0.05);不良反应:观察组白细胞减少、血小板减少、血红蛋白下降、肾功能损害、恶心呕吐等不良反应明显低于对照组(χ2=3.953~6.038,P<0.05)。结论:小柴胡汤辅助化疗有助于缓解晚期肺癌患者全身炎症状态,改善免疫功能,减少不良反应,提高治疗效果。
Objective: To investigate the effects of Xiao Chai Hu Tang adjuvant chemotherapy on inflammatory factors and immune function in patients with advanced lung cancer. Methods: One hundred and twelve patients with advanced lung cancer undergoing hospitalization from May 2012 to November 2014 were selected as study subjects, and randomly divided into observation group (56 cases) and control group (56 cases). Patients in the control group received chemotherapy alone, while patients in the observation group received adjuvant chemotherapy with Xiao Chai Hu Tang. Inflammatory factors, immune function, treatment effects, and adverse reactions were compared between the two groups. Results: The short-term curative effect: The effective rate of the observation group and the disease control rate were significantly higher than those in the control group (46.43% vs 23.21%, 78.57% vs60.71%, respectively) (χ2 = 4.223-6.648, P <0.05) The levels of serum CRP, TNF-α and IL-6 were lower in the patients than those in the control group (t = 14.101-17.437, P <0.05). Immune function: The levels of CD4 + and CD4 + / CD8 + in the observation group were significantly higher than those in the control group, and the levels of CD8 + in the observation group were significantly lower than those in the control group (t = 3.185-7.007, P <0.05). Adverse reactions were: leukopenia, thrombocytopenia, hemoglobin, , Nausea and vomiting and other adverse reactions was significantly lower than the control group (χ2 = 3.953 ~ 6.038, P <0.05). Conclusion: Xiao Chai Hu Tang adjuvant chemotherapy can help alleviate the systemic inflammatory status in patients with advanced lung cancer, improve immune function, reduce adverse reactions and improve the therapeutic effect.