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目的 :观察粘蛋白糖链抗原 ST- 4- 39在肺癌组织中的表达情况 ,探讨 ST- 4- 39抗原与肺癌组织学类型及分化程度的关系。方法 :应用单克隆抗体 ST- 4- 39及 S- P免疫组化染色方法 ,对 5 8例肺癌标本 ,进行糖链抗原ST- 4- 39的检测。结果 :癌周正常肺组织中 ,ST- 4- 39抗原表达阴性。肺癌组织中 ST- 4- 39抗原的表达阳性率为74%。在不同组织学类型肺癌组织中 ,ST- 4- 39抗原阳性表达率分别为鳞癌 5 3% ,腺癌 97% ,大细胞癌 6 0 %、小细胞癌 0 %。鳞癌与腺癌差异性显著 (P <0 .0 1)。在不同组织分化程度的鳞癌中 ,ST- 4- 39抗原阳性表达率为 :高分化6 9%、低分化 33%、未分化 0 %。在不同分化程度的腺癌中 ,高分化 10 0 %、低分化 10 0 %、未分化 5 0 %。结论 :ST- 4-39抗原表达与肺癌组织分型有关 ;ST- 4- 39抗原表达与肺癌组织分化程度呈正相关趋势
Objective : To observe the expression of mucin and sugar chain antigen ST- 4-39 in lung cancer and to investigate the relationship between ST- 4 - 39 antigen and the histological type and differentiation of lung cancer. METHODS: The monoclonal antibody ST-4-39 and S-P immunohistochemical staining were used to detect 58 cases of lung cancer specimens. Results: In the normal lung tissue around the cancer, ST- 4 - 39 antigen was negative. The positive rate of ST-4-5 antigen expression in lung cancer tissues was 74%. In different histological types of lung cancer, the positive expression rates of ST-4-39 antigen were squamous cell carcinoma 5 3%, adenocarcinoma 97%, large cell carcinoma 60%, and small cell carcinoma 0%. Squamous cell carcinoma and adenocarcinoma were significantly different (P < 0.01). Among the squamous cell carcinomas with different degree of differentiation, the positive expression rate of ST- 4 -39 antigen was: high-differentiation rate of 6 9%, poorly-differentiated rate of 33%, and undifferentiated 0%. Among adenocarcinomas with different degrees of differentiation, 100% were highly differentiated, 100% were poorly differentiated, and 50% were undifferentiated. Conclusion : The expression of ST- 4 -39 antigen is related to the lung cancer tissue type. The expression of ST- 4 -39 antigen is positively correlated with the degree of lung cancer tissue differentiation.