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为探讨普伐他汀对冠心病患者外周血单核细胞（ＰＢＭｓ）功能的影响，对２１例血脂正常冠心病患者和９例健康人ＰＢＭｓ粘附分子ＣＤ１１ｂ、ＣＤ４９ｄ表达及ＴＮＦ－α、ＩＬ－８分泌情况进行了检测；并在体外分离培养的冠心病患者ＰＢＭｓ中，观察了普伐他汀对其表达ＣＤ１１ｂ、ＣＤ４９ｄ及分泌ＴＮＦ－α、ＩＬ－８的影响。结果表明：冠心病患者ＰＢＭｓ表达ＣＤ１１ｂ、ＣＤ４９ｄ及分泌ＩＮＦ－α、ＩＬ－８的能力明显高于正常对照组（Ｐ＜００１）；普伐他汀能下调冠心病患者ＰＢＭｓＣＤ１１ｂ、ＣＤ４９ｄ表达及降低ＴＮＦ－α、ＩＬ－８的分泌（Ｐ＜００５）。说明普伐他汀可抑制冠心病患者外周血单核细胞的功能。
To investigate the effect of pravastatin on peripheral blood mononuclear cells (PBMs) in patients with coronary heart disease (CHD), the expressions of CD11b, CD49d and TNF-α, IL-8 The secretion of CD11b, CD49d and the secretion of TNF-α and IL-8 were observed in PBMs of patients with coronary heart disease. The results showed that the expression of CD11b, CD49d and the secretion of INF-α and IL-8 in PBMs of patients with coronary heart disease were significantly higher than those of the normal control group (P <0.01); pravastatin could down-regulate the expression of CD11b and CD49d in patients with coronary heart disease TNF-α, IL-8 secretion (P <0 05). Pravastatin can inhibit the function of peripheral blood mononuclear cells in patients with coronary heart disease.