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A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramolecular tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization.
A short and efficient stereoselective synthesis of a styryllactone (-) - isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the same well available carbohydrate D-mannose. The key steps of our synthesis involve intramolecular tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization.