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目的 :局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔与单纯口服普萘洛尔治疗婴幼儿血管瘤60例,评价其近期效果及不良反应。方法:随机抽取局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔的患儿及单纯口服普萘洛尔治疗血管瘤的患儿各30例,用药前检查结果无异常,用药前、后1 h观察其心率、血压变化;服药后1个月观察有无呕吐、嗜睡、腹泻、局部皮肤反应、肢端发冷及低血糖症状等。采用SPSS 13.0软件包对数据进行统计学处理。结果:2组不良反应例数无显著差异,用药前、后1h内血压、心率变化不明显。结论:局部涂抹0.5%马来酸噻吗洛尔溶液联合口服普萘洛尔与单纯口服普萘洛尔的近期不良反应发生率相近,无严重不良反应发生。
Objective: Topical application of 0.5% timolol maleate solution combined with oral propranolol and oral propranolol in the treatment of infantile hemangiomas in 60 cases, evaluate the short-term effects and adverse reactions. Methods: Thirty children with thromboxane maleate plus propranolol orally and propranolol alone were enrolled in this study. The results of pretreatment tests were normal, 1 h before and after observation of its heart rate, blood pressure changes; 1 month after taking the observation of vomiting, lethargy, diarrhea, local skin reactions, extremities cold and hypoglycemia and so on. The data were statistically processed using SPSS 13.0 software package. Results: There were no significant differences in the number of adverse reactions between the two groups. The changes of blood pressure and heart rate were not obvious within 1 hour before and after treatment. Conclusion: Topical application of 0.5% timolol maleate solution combined with propranolol orally and propranolol orally in the near future have similar adverse reactions, with no serious adverse reactions.