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多年来,非类固醇抗炎药一直是一类重要的治疗药物。但仅在1971年才证明,这些药物是通过抑制前列腺素合成而起作用的。从那以后,非类固醇制剂的应用数量明显增加,使用范围扩大,并增加了对其利弊问题的注意。某些药物的副作用导致了禁止这些药物的生产(例如:保泰松、佐美酸、芬氯酸,和消炎痛的Osmosin制剂)。所有医师都很清楚非类固醇抗炎药会产生一些作用如胃粘膜糜烂,但他们可能未认识到也可出现更严重的副作用,特别是对肾的损害。过去一段时间有偶见的肾功能衰竭病例报
For years, non-steroidal anti-inflammatory drugs have been an important class of therapies. It was only in 1971 that these drugs proved to work by inhibiting prostaglandin synthesis. Since then, there has been a marked increase in the use of non-steroidal agents, their expanded use, and increased attention to their pros and cons. The side effects of certain drugs have led to the banning of the manufacture of these drugs (eg, phenylbutazone, samoate, fenchlorate, and the Osmosin preparation of indomethacin). It is clear to all physicians that non-steroidal anti-inflammatory drugs have some effect such as gastric mucosal erosion, but they may not be aware of the more serious side effects that may occur, especially damage to the kidneys. Occasionally occasional cases of renal failure reported in the past period