论文部分内容阅读
目的了解丙型肝炎病毒（ＨＣＶ）在胃粘膜细胞中的感染状况。方法采用免疫组化Ｓ－Ｐ法以抗－ＨＣＶＮＳ３和抗－ＨＣＶＮＳ５检测了３３例慢性丙型肝炎（ＣＨＣ）患者胃粘膜组织中ＨＣＶＮＳ３及ＨＣＶＮＳ５抗原。结果ＨＣＶＮＳ３、ＨＣＶＮＳ５的检出率分别为３３．３３％（１１／３３）和２７．２７％（９／３３）。阳性物质沉积于胃粘膜上皮腺体细胞胞浆，呈单个或片灶状分布，部分病例淋巴细胞胞浆中也可见到。结论胃粘膜细胞中ＨＣＶ抗原的检出，表明ＨＣＶ可能是一种泛嗜性病毒，其机制及生物学意义须进一步研究。
Objective To understand the infection status of Hepatitis C virus (HCV) in gastric mucosal cells. Methods Immunohistochemical S-P method was used to detect anti-HCV NS3 and anti-HCV NS5 in 33 patients with chronic hepatitis C (CHC) gastric mucosal HCV NS3 and HCV NS5 antigen. Results The detection rates of HCVNS3 and HCVNS5 were 33.33% (11/33) and 27.27% (9/33), respectively. Positive material deposited in the gastric mucosa epithelial gland cytoplasm, was single or focal distribution, some cases can also be seen in the cytoplasm of lymphocytes. Conclusion The detection of HCV antigen in gastric mucosal cells indicates that HCV may be a pan-tropic virus. The mechanism and biological significance of HCV should be further studied.