内皮素与一氧化氮在肝硬变血流动力学紊乱中的作用

• 作 者: 任锡玲 姚希贤
• 机 构: 解放军２７１医院消化科,河北医科大学第二医院内科
• 出 处: 华人消化杂志
• 发表日期: 1998年07期
• 关键词: 血流动力学紊乱 腹水患者 内皮素 血管活性物质 内毒素血症 姚希贤 高动力循环状态 肝硬变腹水 高效液相色谱法 门脉高压

目的研究内皮素、一氧化氮在肝硬变血流动力学紊乱中的作用及关系．方法应用放免法和高效液相色谱法分别检测肝硬变患者４４例，（男３２例，女１２例；年龄５０４岁±１１０岁），其中腹水患者２７例及健康对照２５例（男１８例，女７例；年龄４６８岁±１２４岁）血浆内皮素（ＥＴ）、一氧化氮（ＮＯ）及部分血管活性物质水平．结果肝硬变组血浆ＥＴ及ＮＯ水平（５７０ｎｇ／Ｌ±２５４ｎｇ／Ｌ，３８７２μｇ／Ｌ±１０６４μｇ／Ｌ）明显高于对照组（３３０ｎｇ／Ｌ±１０９ｎｇ／Ｌ，２９２３μｇ／Ｌ±５４５μｇ／Ｌ，Ｐ＜００１）．腹水患者血浆ＥＴ及ＮＯ水平（６７５ｎｇ／Ｌ±２４７ｎｇ／Ｌ，４１４７μｇ／Ｌ±１０７１μｇ／Ｌ），显著高于无腹水患者（４５９ｎｇ／Ｌ±１８３ｎｇ／Ｌ，３２７２μｇ／Ｌ±７０２μｇ／Ｌ，Ｐ＜００１）．ＮＯ与ＥＴ呈直线正相关（ｒ＝０７７２，Ｐ＜００１）．结论肝硬变患者ＥＴ与ＮＯ水平升高，且腹水患者较无腹水者更升高；两者呈直线正相关

Objective To investigate the role and relationship of endothelin and nitric oxide in hemodynamic disorders of liver cirrhosis. Methods 44 patients with cirrhosis were detected by radioimmunoassay (RIA) and high performance liquid chromatography (32 males and 12 females; age 50.4 ± 11.0 years). Among them, 27 patients with ascites and 25 healthy controls (18 males and 7 females; age 46.8 years ± 12.4 years), the levels of plasma endothelin (ET), nitric oxide (NO) and some vasoactive substances. Results The levels of plasma ET and NO in cirrhosis group were significantly higher than those in control group (570ng / L ± 254ng / L, 3872μg / L ± 1064μg / L, 330ng / L ± 109ng / L, 2923μg / L ± 545μg / L, P <001). The levels of plasma ET and NO in patients with ascites (675ng / L ± 247ng / L, 4147μg / L ± 1071μg / L) were significantly higher than those without ascites (459ng / L ± 183ng / L, 3272μg / L ± 702 μg / L, P <001). There was a linear positive correlation between NO and ET (r = 0772, P <001). Conclusion The levels of ET and NO in patients with cirrhosis are higher than those in patients without ascites, and there is a positive correlation between them