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卵巢恶性肿瘤的治疗,在肿瘤化学治疗史上是较成功的。在过去的30年中,由于组织学分类和命名的标准化,及有效的联合化疗的确定和不断改进,使卵巢恶性肿瘤的治疗效果明显提高。对卵巢癌的处理包括外科手术切除及手术化疗的综合治疗,二者缺一不可,无论是上皮癌、恶性生殖细胞瘤及其他组织类型的恶性肿瘤,先期化疗、术后化疗都是非常重要的[1]。回顾分析国内外化疗药物的应用,从70年代应用噻替派、马法兰、5-氟尿嘧啶、氨甲碟呤,更生霉素等药到80年代开始应用顺铂以及近10余年来逐渐完善的联合化疗方案,如VAC方案(V-长春新碱、A-放射菌素D、C-环鳞酰胺)、PVB方案(P-顺铂、V-长春新碱、B-博莱霉素)、BEP方案(B-博莱霉素、E-足叶乙甙、P-顺铂)等方案。这些方案使卵巢患者的存活率不断提高,取得了较好的治疗效果。
The treatment of ovarian cancer, the history of cancer chemotherapy is more successful. In the past 30 years, due to the standardization of histological classification and nomenclature, and the determination and continuous improvement of effective combination chemotherapy, the treatment effect of malignant ovarian tumors has been significantly improved. The treatment of ovarian cancer, including surgical resection and surgical chemotherapy combined treatment, both indispensable, whether it is epithelial cancer, malignant germ cell tumors and other types of malignant tumors, pre-chemotherapy, postoperative chemotherapy are very important [1]. Review of the application of chemotherapy drugs at home and abroad, from the 70’s application of thiotepa, melphalan, 5-fluorouracil, methotrexate, dactinomycin and other drugs to the 80’s began to use cisplatin and gradually more than 10 years of combined chemotherapy Regimens such as the VAC regimen (V-vincristine, A-actinomycin D, C-cyclin), the PVB regimen (P- cisplatin, V- vincristine, B-bleomycin) (B-bleomycin, E-etoposide, P-cisplatin) and other programs. These programs enable patients with ovarian survival rate continues to improve, and achieved good therapeutic effect.