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目的:探讨妊娠期糖尿病患者血清C-反应蛋(CRP)、白细胞介素6(IL-6)水平变化及其与胰岛素抵抗、血脂的关系。方法:采用放射免疫法测定妊娠24～28周无孕前肥胖的30例妊娠期糖尿病孕妇(GDM组)和30例正常妊娠晚期孕妇(正常妊娠组)的空腹血清IL-6水平,同时测定两组孕妇血清CRP、空腹血糖(FBS)、胰岛素(FINS)、C肽、总胆固醇(TG)和甘油三酯(TC)水平,并计算孕前体重指数(BMI)、胰岛素抵抗指数(HOMA-IRI)以评价胰岛素抵抗程度。结果:两组孕妇空腹血清CRP、IL-6、FBS、F INS、C肽、HOMA-IRI、TG水平及孕前BMI比较,差异有统计学意义(P<0.01或P<0.05),而血清TC水平比较差异无统计学意义(P>0.05);CRP和IL-6的水平分别与HOMA-IRI、TG呈正相关性(r=0.886,0.792,P<0.05;r=0.685,0.767,P<0.05),与TC无相关性(P>0.05)。结论:在无孕前肥胖状况下,妊娠期糖尿病患者血清CRP、IL-6水平的升高与胰岛素抵抗、血脂指标异常有关。
Objective: To investigate the changes of serum C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with gestational diabetes mellitus and their relationship with insulin resistance and blood lipid. Methods: The levels of fasting serum IL-6 in 30 pregnant women with gestational diabetes mellitus (GDM group) and 30 normal pregnant women (normal pregnancy group) were measured by radioimmunoassay The levels of serum CRP, FBS, FINS, C-peptide, total cholesterol (TG) and triglyceride (TC) in pregnant women were calculated and the body mass index (BMI) and insulin resistance index (HOMA-IRI) Evaluation of insulin resistance. Results: The levels of fasting serum CRP, IL-6, FBS, F INS, C-peptide, HOMA-IRI and TG in pregnant women were significantly different from those before pregnancy (P <0.01 or P < (P> 0.05). The levels of CRP and IL-6 were positively correlated with HOMA-IRI and TG respectively (r = 0.886,0.792, P <0.05; r = 0.685,0.767, P <0.05 ), No correlation with TC (P> 0.05). Conclusion: In the condition of pre-pregnancy obesity, the elevated serum levels of CRP and IL-6 in patients with gestational diabetes mellitus are associated with abnormal insulin resistance and dyslipidemia.