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目的研究支气管哮喘患儿急性发作期及其缓解期支气管诱导痰液中炎细胞变化及临床意义。方法选择2002-02—2002-12在中国医大二院儿童哮喘门诊就诊的哮喘患儿,其中哮喘急性发作期34例;哮喘缓解期30例;健康对照组22例。比较哮喘不同病程之间以及不同病程与正常儿童之间支气管诱导痰液细胞成分的差异。结果哮喘患儿急性发作期支气管诱导痰液中,中性粒细胞占细胞总数的百分比明显高于缓解期及正常对照组(均P<0.01)。哮喘急性发作期、缓解期诱导痰液中嗜酸细胞占总数的百分比均明显高于正常对照组,差异显著(P<0.01)。结论支气管哮喘是一种慢性气道炎症性疾病,在不同发病时期气道内的炎细胞变化不同。
Objective To study the changes and clinical significance of inflammatory cells in sputum induced by bronchus during acute attack and remission in children with bronchial asthma. Methods From February 2002 to February 2002, 34 asthmatic children with asthma exacerbation were included in the pediatric asthma clinic of the Second Affiliated Hospital of China Medical University; 30 cases of asthma remission; and 22 healthy controls. The differences of bronchial-induced sputum cell components between different stages of asthma and between different stages and normal children were compared. Results The percentages of neutrophils in the bronchial sputum induced by acute exacerbation of asthmatic children were significantly higher than those in remission and normal control groups (all P <0.01). The percentage of eosinophils in sputum induced by acute phase of asthma was significantly higher than that of normal control group (P <0.01). Conclusions Bronchial asthma is a chronic airway inflammatory disease with different changes of inflammatory cells in the airway at different stages of onset.