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目的:评价长期中等强度运动训练对慢性心力衰竭患者血浆心脏型脂肪酸结合蛋白的影响。方法:药物标准治疗的60例心力衰竭患者随机分为2组:6个月运动训练组(Ⅰ组,30例),非运动训练组(Ⅱ组,30例)。在体检时正常人组(正常对照组,30例),Ⅰ组及Ⅱ组观察前后抽血,查血清脑钠肽(BNP)及心脏型脂肪酸结合蛋白(H-FABP)。结果:半年后,慢性心力衰竭患者Ⅰ组及Ⅱ组治疗前血清BNP分别为(357±32)、(343±14)g/L,H-FABP分别为(15.5±3.1)、(13.0±5.4)mg/L,均显著高于无心力衰竭正常对照组的BNP(36±4)g/L及H-FABP(4.1±2.3)mg/L(P<0.05);Ⅰ组运动后,BNP自(357±32)g/L降至(104±41)g/L,H-FABP自(15.5±3.1)mg/L降至(6.1±4)mg/L;Ⅱ组治疗后,BNP自(343±14)g/L降至(165±20)g/L;H-FABP自(13.0±5.4)mg/L降至(8.2±5.1)mg/L。结论:长期适当的运动训练,可使慢性心力衰竭患者血浆心脏型脂肪酸结合蛋白的水平下降。
Objective: To evaluate the effect of long-term moderate-intensity exercise training on plasma cardiac fatty acid-binding protein in patients with chronic heart failure. Methods: Sixty patients with heart failure treated by standard medicine were randomly divided into two groups: 6-month exercise training group (group Ⅰ, 30 cases) and non-exercise training group (group Ⅱ, 30 cases). At the time of examination, blood samples were taken from normal subjects (normal control group, 30 cases), group Ⅰ and group Ⅱ before and after the observation. Serum brain natriuretic peptide (BNP) and cardiac fatty acid binding protein (H-FABP) were detected. Results: After six months, the BNP levels in patients with chronic heart failure before treatment were (357 ± 32) and (343 ± 14) g / L, respectively, and the H-FABP were 15.5 ± 3.1 and 13.0 ± 5.4 ) mg / L were significantly higher than those of BNP (36 ± 4) g / L and H-FABP (4.1 ± 2.3) mg / L in normal control group without heart failure (357 ± 32) g / L to (104 ± 41) g / L and H-FABP from (15.5 ± 3.1) mg / L to (6.1 ± 4) mg / 343 ± 14) g / L to (165 ± 20) g / L; H-FABP decreased from (13.0 ± 5.4) mg / L to (8.2 ± 5.1) mg / L. Conclusion: Long-term proper exercise training can reduce the level of plasma cardiac fatty acid-binding protein in patients with chronic heart failure.