阿司匹林对急性脑梗死患者血浆一氧化氮及血小板α颗粒膜蛋白的影响

• 作 者: 王丹 朱浩佳 梁焯辉 王小朝
• 机 构: 广东省江门市人民医院神经内科,广东省江门市人民医院神经内科,广东省江门市人民医院神经内科,广东省江门市人民医院检验科 (529000),(529000),(529000),(529000)
• 出 处: 中国实用内科杂志
• 发表日期: 2004年12期
• 关键词: 阿司匹林 脑梗死 一氧化氮 血小板α颗粒蛋白

目的　探讨阿司匹林对急性脑梗死患者血浆一氧化氮 (NO)及血小板α颗粒膜蛋白 (GMP 14 0 )的影响。方法　 2 0 0 2 - 0 5～ 2 0 0 3- 0 8广东江门市人民医院 78例急性脑梗死患者随机分为 4 0例治疗组和 38例对照组 ,采用硝酸酶还原法和双抗体夹心酶联免疫吸附法分别测定治疗组和对照组的血浆NO及GMP 14 0的含量。治疗组患者经过阿司匹林治疗后 2周 ,再次测定治疗组和对照组的血浆NO及GMP 14 0的含量。结果　治疗组治疗后患者血浆NO及GMP 14 0水平较对照组治疗后明显下降 (P <0 0 1) ,治疗组治疗后的ESS分值高于对照组治疗后的ESS分值 (P <0 0 1)。结论　阿司匹林能通过降低急性脑梗死患者血浆NO及GMP 14 0的水平 ,从而减轻缺血性脑损伤 ,起到脑保护作用。

Objective To investigate the effects of aspirin on plasma nitric oxide (NO) and platelet α-granule membrane protein (GMP-140) in patients with acute cerebral infarction. Methods 2 0 0 2 - 0 5 ~ 2 0 0 3- 0 8 78 cases of acute cerebral infarction in Jiangmen People’s Hospital of Guangdong were randomly divided into 40 treatment groups and 38 control groups. Nitrolase reduction and double antibody sandwich Enzyme-linked immunosorbent assay was used to determine plasma NO and GMP-140 levels in the treated and control groups, respectively. The patients in the treatment group were treated with aspirin for 2 weeks, and the levels of plasma NO and GMP 14 0 in the treatment group and the control group were measured again. Results The plasma levels of NO and GMP-140 in the treatment group were significantly lower than those in the control group (P <0.01), and the ESS scores of the treatment group were higher than those of the control group after treatment (P <0 0 1). Conclusion Aspirin can reduce the level of NO and GMP-140 in plasma of patients with acute cerebral infarction, and thus reduce the ischemic brain injury and play a neuroprotective role.