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目的:分析不同发病孕周早发型重度子痫前期疾病对围产期母婴结局的影响。方法:对138例不同孕周的早发型重度子痫前期进行回顾性分析。根据发病孕周分成A组(孕周<28周)41例、B组(28周≤孕周<32周)52例、C组(32周<孕周<34周)45例。结果:3组间患者并发症发率无统计学差异(P>0.05);3组间新生儿窒息率及新生儿死亡率有统计学差异(P<0.05),随着孕周延长而下降;终止妊娠方式A组主要为引产,B、C组主要为剖宫产,A组与B、C组有统计学差异(P<0.05);B组期待治疗的时间显著长于其他两组(P<0.05)。结论:早发型重度子痫前期新生儿窒息率和围生儿死亡率随发病孕周延长而降低,应严格选择病例进行期待治疗,并严密监测母胎情况,适时选择合适的方式终止妊娠。
OBJECTIVE: To analyze the effect of early onset severe pre-eclampsia in different gestational weeks on perinatal maternal and infant outcomes. Methods: A retrospective analysis of 138 cases of gestational age with early-onset severe preeclampsia. There were 41 cases in group A (gestational age <28 weeks), 52 cases in group B (28 weeks ≤ gestational weeks <32 weeks) and 45 cases in group C (32 weeks 0.05). The rates of neonatal asphyxia and neonatal mortality were significantly different between the three groups (P <0.05), and decreased with the prolonged gestational age. The termination of pregnancy was mainly induced by labor in group A, mainly in cesarean section in groups B and C, and statistically significant differences in group A and B and C (P <0.05). The duration of treatment in group B was significantly longer than that in the other two groups (P < 0.05). Conclusion: Asphyxia and perinatal mortality in early-onset severe preeclampsia decrease with the prolongation of gestational age. Serious cases should be selected for treatment and the mother’s fetus should be closely monitored. The right way to terminate pregnancy should be timely.