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肝纤维化是细胞外基质不断累积增加的过程,可以影响组织内的分子扩散和血流微循环,最后导致威胁生命的情况发生,比如肝硬化、原发性肝癌,甚至肝衰竭等~([1])。目前,经皮穿刺肝活检被公认是诊断肝纤维化并进行肝纤维化分级诊断的“金标准”~([2])。但是,活检属于有创性检查,且造价昂贵、操作繁琐、样本量有限,很难进行重复检查,存在一定的风险,因此不能作为诊断肝纤维化分级的常规检查。肝纤维化早期,病理分级在F0~2级时,临床中定义为轻中度肝
Liver fibrosis is a process of cumulative accumulation of extracellular matrix that can affect molecular diffusion and blood flow microcirculation within the tissue, leading to life-threatening conditions such as cirrhosis, primary liver cancer and even liver failure [ 1]). Currently, percutaneous biopsy is recognized as a liver biopsy diagnosis of liver fibrosis and grading the diagnosis of “gold standard ” ~ ([2]). However, biopsy is invasive and costly, cumbersome to operate, limited in sample size, difficult to perform double check, and has certain risks. Therefore, biopsy can not be used as a routine check for the classification of liver fibrosis. Early liver fibrosis, pathological grade F0 ~ 2, clinically defined as mild to moderate liver