论文部分内容阅读
丙炔苯丙胺是治疗Parkinson病的神经保护剂,已日益被重视。人类和动物实验已证实,四氢吡啶经单胺氧化酶—B催化反应转化为强亲和毒素,可选择性损害多巴胺神经元致Parkinson病。丙炔苯丙胺可以阻止强亲和毒素的氧化,保护线粒体复合物Ⅰ。保护细胞代谢中ATP合成和谷胱甘肽的再生。可使铁池起反应前的过氧化氢形成减少,预防因羟基根形成而加速的残余多巴胺神经元变性,其次通过代谢产生的苯乙胺增加多巴胺能的反应。临床研究证明,丙炔苯丙胺可延迟左旋多巴的需要,延迟病情进展。
Propynidine is a neuroprotective agent for the treatment of Parkinson’s disease and has gained increasing attention. Human and animal experiments have confirmed that tetrahydropyridine is converted to a strong affinity toxin via monoamine oxidase-B catalysis and selectively damages dopamine neurons to Parkinson’s disease. Propargyl inhibits the oxidation of strong affinity toxins and protects mitochondrial complexes. Protecting Cell Metabolism in ATP Synthesis and Glutathione Regeneration. Can reduce the formation of hydrogen peroxide before reaction of the iron pool, prevent the remnants of residual dopamine neurons from accelerating due to the formation of hydroxyl radicals, and secondly, increase the dopaminergic reaction by metabolizing phenethylamine. Clinical studies have shown that propargyl can delay the need for levodopa, delay the progression of the disease.