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目的:探讨cFLIP基因在胃癌组织中表达状况及其与胃癌发生发展的关系.方法:采用免疫组化法检测cFLIPshort/long基因在48例胃癌、48例肠化胃黏膜及42例慢性胃炎黏膜中的表达,并经计算机图像分析,计算阳性细胞百分率.统计采用方差分析.结果:cFLIPshort/long基因全部表达于胃癌组织,部分表达于肠化胃黏膜及慢性胃炎黏膜.胃癌组织中cFLIP基因表达强度(强阳性占70.8%)显著高于肠化胃黏膜(P<0.01)及慢性胃炎黏膜(P<0.01),且与胃癌浸润深度(P<0.05),胃癌TNM分期(P<0.05)显著相关.而肠化胃黏膜与慢性胃炎中cFLIP基因表达差异无显著性(P>0.05).结论:cFLIPshort/long基因特异性高表达于胃癌组织且在胃癌转化过程中是一较晚期事件,与胃癌的发生及浸润转移密切相关.
Objective: To investigate the expression of cFLIP gene in gastric carcinoma and its relationship with the occurrence and development of gastric cancer.Methods: The expression of cFLIPshort / long gene in 48 gastric carcinoma, 48 intestinal mucosa and 42 chronic gastritis mucosa were detected by immunohistochemistry And the percentage of positive cells was calculated by computer image analysis.Results: The expression of cFLIPshort / long gene was all expressed in gastric cancer tissue and partly in intestinal mucosa and chronic gastritis mucosa.Expression intensity of cFLIP gene in gastric cancer (70.8%) were significantly higher than those in intestinal mucosa (P <0.01) and chronic gastritis mucosa (P <0.01), and were significantly correlated with the depth of gastric cancer invasion (P <0.05) (P> 0.05) .Conclusion: cFLIPshort / long gene is highly expressed in gastric cancer tissues and is a more advanced event in the process of gastric cancer transformation, which is associated with gastric cancer The occurrence and invasion and metastasis are closely related.