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目的 探讨HBO对动物牙周炎和牙龈血流量（GBF）的影响及疗效维持时间。方法 用丝线缝扎加喂含10％糖的食料,形成实验性牙周炎,每日1次用0.25MPa HBO暴露60min,连续2周,观察治疗结束当时（10周）和结束后1月（14周）各牙周指标,并用激光多普勒血流仪测定GBF。结果HBO组在10周和14周时牙龈指数（GI）、菌斑指数（PLI）比牙周炎组明显降低（P<0.01）,牙周袋深度（PD）、牙周附着丧失（AL）、牙松动度（TO）比牙周炎组轻度降低（P<0.05）,10周时GBF比牙周炎组明显增加。14周时各牙周指标和GBF与10周时数值接近（P>0.05）。结论 HBO治疗后牙周各临床指标均降低,对GI和PLI作用最强,对PD、AL和TO有一定作用,治疗后GBF明显增加,并维持1月以上。
Objective To investigate the effects of HBO on periodontitis and gingival blood flow (GBF) in animals and its duration of maintenance. Methods Suture was fed with 10% sugar to form experimental periodontitis. The rats were exposed to 0.25MPa HBO once a day for 60min, and then observed for two weeks at the end of treatment (10 weeks) and after January 14 weeks) of each periodontal index, and measured by laser Doppler flowmetry GBF. Results The gingival index (GI) and plaque index (PLI) of HBO group were significantly lower than those of periodontitis group at 10 and 14 weeks (P <0.01) , Tooth mobility (TO) slightly lower than the periodontitis group (P <0.05), GBF than the periodontitis group significantly increased at 10 weeks. At 14 weeks, each periodontal index and GBF were close to 10 weeks (P> 0.05). Conclusion All clinical indexes of periodontal tissue decrease after HBO treatment, and have the strongest effect on GI and PLI. They have a certain effect on PD, AL and TO. The GBF after treatment is obviously increased and maintained for more than one month.