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目的评价慢性阻塞性肺疾病急性加重的诊断和治疗中降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)水平检测的临床意义。方法选取2011-03/2013-06月间来作者医院呼吸科诊治的慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者164例,通过检测稳定期(80例)与急性加重期(84例)患者的PCT以及CRP含量,评价两者对于COPD急性加重(acute chronic obstructive pulmonary disease,AECOPD)的诊断意义,同时临床根据PCT与CRP水平进行指导治疗,评价两者在COPD治疗中的指导作用。结果 AECOPD组的PCT、CRP表达水平与COPD组相比显著升高;治疗COPD后发现,两组患者的治疗有效率比较,差异无统计学意义(P>0.05);指导治疗组患者AECOPD发生率与常规治疗组相比发生率下降,但组间差异无统计学意义(P>0.05);但对于住院时间、抗菌治疗时间、二重感染率而言,指导治疗组较常规治疗组显著减少(P<0.05)。结论 PCT、CRP能够作为早期诊断AECOPD的血清学指标,同时PCT、CRP检测用于指导COPD的临床治疗,缩短了患者的住院时间,显著降低了抗菌药物的使用和二重感染的发生,值得在临床上广泛使用。
Objective To evaluate the clinical significance of the detection of procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 164 patients with chronic obstructive pulmonary disease (COPD) diagnosed and treated by Department of Respiratory Medicine from 2011-03 / 2013-06 were enrolled in this study. The relationship between stable (80 cases) and acute exacerbation (84 cases ) In patients with chronic obstructive pulmonary disease (COPD). The PCT and CRP levels were evaluated to evaluate the diagnostic value of both of them in patients with acute chronic obstructive pulmonary disease (COPD). At the same time, clinical guidelines were given according to the level of PCT and CRP. Results The levels of PCT and CRP in AECOPD group were significantly higher than those in COPD group. There was no significant difference in therapeutic efficiency between the two groups (P> 0.05) after treatment of COPD. The incidence of AECOPD Compared with the conventional treatment group, the incidence decreased, but there was no significant difference between the two groups (P> 0.05). However, the duration of hospitalization, antibacterial treatment time and the rate of double infection were significantly decreased P <0.05). Conclusions PCT and CRP can be used as early serological markers for the diagnosis of AECOPD. At the same time, the detection of PCT and CRP can guide the clinical treatment of COPD, shorten the hospitalization time and significantly reduce the use of antibiotics and double infection. Widely used clinically.