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采用肿瘤内直接注射法考察了含有~(131)I和丝裂霉素C的多功能抗肿瘤明胶微球(~(131I-MMC-GM)对荷H_(22)肿瘤模型小鼠的抗肿瘤效果。实验结果表明,~(131)I-MMC-GM与单独使用~(131)I或MMC比较,具有更高的生物利用度和药物分布专一性。经肿瘤内注射后,~(131)1-MMC-GM滞留在肿瘤组织之间产生持续的治疗和化疗作用,从而导致肿瘤细胞大面积凝固性坏死。~(131)1-MMC-GM实验组小鼠H~(22)肿瘤增长速度明显地受到抑制,其生存期明显地延长。
Intratumoral injection of 131I-MMC-GM-containing multi-functional anti-tumor gelatin microspheres (131I-MMC-GM) was used to investigate the anti-tumor effect of H22 tumor-bearing mice. The results showed that ~(131)I-MMC-GM had higher bioavailability and drug distribution specificity compared with 131I or MMC alone. After intratumoral injection, ~(131) ) 1-MMC-GM stays in the tumor tissue and produces continuous therapeutic and chemotherapeutic effects resulting in large area of coagulative necrosis of tumor cells. The growth of H22 tumors in 131(131)1-MMC-GM mice The speed is significantly suppressed, and its survival period is significantly longer.