论文部分内容阅读
成熟卵泡合成的雌激素不但参与调节垂体促性腺激素的释放,促进副性器官的发育,而且刺激卵巢颗粒细胞增生,诱导颗粒细胞中雌激素受体的生成并增加细胞间的裂隙连结(gap junction).此外,雌激素与促卵泡成熟激素(FSH)协同作用可使卵泡腔形成,也诱导颗粒细胞生成促黄体生成激素(LH)受体.无排卵的妇女服用枸橼酸克罗米芬可增高循环中促性腺激素和雌激素的水平,导致卵泡成熟和排卵.推测克罗米芬与垂体和下丘脑的雌激素受体结合后,刺激促性腺激素的释放,但不能排除克罗米
Mature follicles not only involved in the synthesis of estrogen regulation of pituitary gonadotropin release, promote the development of the secondary sex organs, but also stimulate the proliferation of ovarian granulosa cells, induce granulosa estrogen receptor production and increase cell gap junction (gap junction) In addition, the synergistic effect of estrogen and follicle stimulating hormone (FSH) can induce the formation of follicular cavity and induce the production of luteinizing hormone receptor (LH) by granulosa cells. Clomiphene citrate increases the circulation in anovulatory women Gonadotropin and estrogen levels, leading to follicular maturation and ovulation.It is speculated that clomiphene and pituitary and hypothalamic estrogen receptor binding, stimulate the release of gonadotropin, but can not be ruled out croton