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目的探讨双水平气道正压通气(Bi PAP)辅助治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的临床效果。方法选取2013年5月-2015年5月医院呼吸科收治COPD合并Ⅱ型呼吸衰竭患者76例,随机分为试验组与对照组各38例。对照组予常规治疗,试验组予Bi PAP治疗,比较2组临床效果及患者临床指征改善情况。结果试验组总有效率94.74%明显高于对照组的73.68%,差异有统计学意义(P<0.05)。试验组治疗后氧分压(Pa O2)、二氧化碳分压(Pa CO2)、呼吸(RR)、心率(HR)及p H值等指标改善明显优于对照组,差异有统计学意义(P<0.05)。结论双水平气道正压通气(Bi PAP)辅助治疗COPD合并Ⅱ型呼吸衰竭临床效果显著,可有效改善患者各项生化指标及临床指征,值得临床推广应用。
Objective To investigate the clinical effect of bi-level positive airway pressure (Bi PAP) in the treatment of chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure. Methods From May 2013 to May 2015, 76 patients with COPD and type Ⅱ respiratory failure admitted to the Department of Respiratory Medicine of the Hospital were randomly divided into experimental group and control group, with 38 cases in each group. The control group was given routine treatment. The experimental group was treated with Bi-PAP. The clinical effect and clinical indications of the two groups were compared. Results The total effective rate was 94.74% in the experimental group was significantly higher than 73.68% in the control group, the difference was statistically significant (P <0.05). The PaO2, PaCO2, RR, HR and p H values of the experimental group were significantly improved after treatment compared with the control group, the difference was statistically significant (P < 0.05). Conclusions Bi PAP is an effective adjuvant therapy for COPD with type Ⅱ respiratory failure. It can effectively improve various biochemical indexes and clinical indications in patients with COPD and is worthy of clinical application.