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目的 :观察干扰素α 1b(赛若金 )对慢性乙型肝炎的疗效及不良反应 ;研究慢性乙型肝炎患者外周血淋巴细胞中细胞因子的表达特点 ,及其与干扰素α疗效的关系。方法 :收集 2 7例慢性乙型肝炎病例 ,以干扰素α 1b 5 0 0万IU深部皮下注射 ,每周 3次 ,治疗 5个月 ,观察疗效和不良反应 ;ELISA法动态监测治疗前后血清IFN γ和IL 4水平。结果 :较正常对照组 ,慢性乙型肝炎患者IFN γ水平均低 (P >0 .0 5 ) ,IL 4水平显著性升高 (P <0 .0 5 ) ;较治疗前 ,显效者 5月后IFN γ水平显著性升高 (P <0 .0 5 ) ,3和 5月后IL 4水平显著性下降 (P <0 .0 5 )。赛若金总有效率 66.6% ,不良反应为一过性和可逆性 ,均未中止治疗。结论 :慢性乙型肝炎患者外周血淋巴细胞中细胞因子的表达与干扰素α的疗效密切相关 ,且以Th2类占优势 ,其可能与乙型肝炎慢性化有关。干扰素α为治疗乙型肝炎疗效确切 ,不良反应轻微。
OBJECTIVE: To observe the efficacy and adverse reactions of interferon alfa 1b in chronic hepatitis B. To study the expression of cytokines in peripheral blood lymphocytes of patients with chronic hepatitis B and its relationship with the efficacy of interferon alfa. Methods: Twenty-seven cases of chronic hepatitis B were collected and subcutaneously injected subcutaneously with interferon α 1b 50 million IU three times a week for 5 months to observe the curative effect and adverse reactions. The levels of serum IFN γ and IL 4 levels. Results: Compared with the normal control group, the levels of IFN-γin patients with chronic hepatitis B were significantly lower (P <0.05) and the levels of IL-4 were significantly higher in patients with chronic hepatitis B (P <0.05) After IFN γ levels were significantly increased (P <0.05), IL-4 levels decreased significantly after 3 and 5 months (P <0.05). If the total efficiency of race gold 66.6%, adverse reactions were transient and reversible, did not stop treatment. Conclusion: The expression of cytokines in peripheral blood lymphocytes of patients with chronic hepatitis B is closely related to the efficacy of interferon α, and is predominantly Th2, which may be related to the chronicity of hepatitis B. Interferon alpha for the treatment of hepatitis B exact effect, minor adverse reactions.