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Angew.Chem.Int.Ed.2017,56,6641~6645过渡金属催化的基于碳-氢键活化的不对称串联反应,能够以简单、廉价的底物一步构建复杂多样的手性化合物.这类反应的难点在于寻找合适的手性配体,同时兼顾碳-氢活化的活性与后续反应的立体选择性控制.中国科学技术大学韩志勇小组以芳基脲为底物,利用碳-氢活化过程产生芳基钯中间体,进而与1,3-二烯发生烯烃插入/分子
Angew.Chem.Int.Ed.2017,56,6641 ~ 6645 Transition metal-catalyzed asymmetric tandem reactions based on carbon-hydrogen bond activation enable the synthesis of complex and diverse chiral compounds in one step using simple, inexpensive substrates. The difficulty of the reaction is to find suitable chiral ligands while taking into account the stereoselective control of the carbon-hydrogen activation activity and the subsequent reaction.University of Science and Technology of China, Han Zhiyong’s group uses the arylurea as a substrate to generate carbon-hydrogen activation Aryl palladium intermediates, which in turn undergo olefin intercalation with 1,3-dienes