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[Objective]To research the pharmacodynamic effects of Aquilaria sinensis leaves,and to compare pharmacological actions between A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM. [Methods]Pharmacological experiments of analgesia,anti-inflammation,hypoglycemic action,relieving asthma and promoting intestine moving activity were carried out by whole animal tests. [Results] glucose values of diabetic mice induced by alloxan reduced significantly in LIGNUM AQUILARIAE RESINATUM group and high-dosage group of A. sinensis leaves( P < 0. 05 or P < 0. 01). Different dosage groups of A. sinensis leaves had extremely significant inhibitory effects on the auricle swelling of mice induced by xylene and the abdominal capillary permeability of mice induced by acetic acid( P < 0. 01 or P < 0. 05). Low- and middle-dosage groups of A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM group had significant inhibitory effects on pains induced by thermal stimulus and acetic acid( P < 0. 05 or P < 0. 01),and obviously prolonged the asthma latency time of guinea pigs( P < 0. 05);and high-dosage group of A. sinensis leaves also obviously prolonged the asthma latency time of guinea pigs( P < 0. 05). Water extracts of A. sinensis leaves showed significant differences in time to falling asleep and sleeping time of mice( P < 0. 01 or P < 0. 05). Different dosage groups of A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM group significantly enhanced the intestine moving distance and rate( P < 0. 05,P < 0. 01 or 0. 001). [Conclusions]Ethanol extracts from A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM had certain functions ofanalgesia,anti-inflammation,hypoglycemic action,relieving asthma and promoting intestine moving activity. Effects of ethanol extracts from A. sinensis leaves were equal to the effects of LIGNUM AQUILARIAE RESINATUM; and the ethanol extracts from A. sinensis leaves was superior to LIGNUM AQUILARIAE RESINATUM in anti-asthma and promoting intestine moving activity.