论文部分内容阅读
CRP是Tillett和Francis于1930年首次在急性大叶性肺炎患者血清中发现的一种能在Ca~(2+)存在时与肺炎球菌细胞壁中C多糖发生特异性沉淀反应的物质,后被证实为一种急性时相反应蛋白。在急性创伤和感染性炎症时,CRP可明显升高。作为衡量疾病急性期的敏感指标,CRP因不受性别、年龄、贫血、高球蛋白血症、妊娠等因素的影响,优于其他炎性反应物质。近年来,CRP在心血管疾病诊治中的应用日益广泛。1 CRP的生化特性 C-反应蛋白(CRP)是由5个完全相同的球形单体相互以非共价形式构成的对称的环状五球体(pentraxin),分子量为118,000。CRP主要在肝脏合成。
CRP was first identified by Tillett and Francis in the serum of patients with acute lobar pneumonia in 1930 as a substance that specifically precipitates C polysaccharide from the pneumococcal cell wall in the presence of Ca 2+ An acute phase reaction protein. In acute traumatic and infectious inflammation, CRP can be significantly increased. As a sensitive indicator of the acute phase of disease, CRP is superior to other inflammatory response substances because of its gender, age, anemia, hypergammaglobulinemia, pregnancy and other factors. In recent years, CRP in the diagnosis and treatment of cardiovascular disease is increasingly widespread. 1 The biochemical characteristics of CRP C-reactive protein (CRP) is a symmetrical pentraxin composed of five identical spherical monomers in non-covalent form with a molecular weight of 118,000. CRP is synthesized mainly in the liver.