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草酸盐沉积症(Oxalosis)是指草酸盐沉着于软组织及其引起的异物反应慢性炎症、纤维变性或肉芽肿形成等。沉着的软组织包括肾脏及其它肾外组织,如心肌、甲状腺等;其次为脾、肺,偶尔也见于淋巴结。草酸盐是无用的代谢终产物,主要由乙醛酸盐(Glyoxylate)代谢而来,乙醛酸盐代谢过程中任何可促使它增多的环节失常均易导致尿中草酸盐排出增多。尿中少量的草酸盐也可来自抗坏血酸。体内正常量的草酸盐一般是无毒性的,但大量的草酸盐则可导致严重的病变,甚至致死。急性中毒时可引起低血钙、抽搐及凝血机制障碍,见于少数自杀病例的报道。慢性中毒时血中积聚过量草酸盐并从尿中排出增多,致肾结石、肾纤维化或肾功能衰竭。草酸盐沉积症唯一易于被检测出的依据是尿中排出过多的草酸盐,即所谓的高草酸盐尿症。虽然,草酸盐(主要是草酸钙)是大多数肾结石的主要成分,但多数患者尿中排出仍在正常范围内。因此,高草酸
Oxalosis refers to the oxalate deposition in soft tissue and the foreign body caused by its chronic inflammation, fibrosis or granuloma formation. Calm soft tissue, including the kidneys and other extrarenal tissues, such as myocardium, thyroid, etc .; followed by the spleen, lungs, occasionally seen in lymph nodes. Oxalate is a useless end product of metabolism, mainly from the glyoxylate (Glyoxylate) metabolism, glyoxylate metabolism can promote its increase in all aspects of disorders are easily lead to urinary oxalate increased. Small amounts of oxalate in urine can also come from ascorbic acid. The normal amount of oxalate in the body is generally non-toxic, but a large amount of oxalate can cause serious disease, or even death. Acute poisoning can cause hypocalcemia, convulsions and coagulation disorders, found in a few cases of suicide. Chronic poisoning in the blood accumulation of excess oxalate and excretion from the urine increased, causing kidney stones, renal fibrosis or renal failure. The only readily detectable basis for oxalate deposits is urinary excretion of oxalate, the so-called hyperoxaluria. Although oxalate (mainly calcium oxalate) is the major component of most kidney stones, most patients are still excreted in the urine in the normal range. Therefore, high oxalic acid