Two Small Molecules, ZCL278 and AZA197 Show Promise in Influencing Protein Interactions Involving th

• 作 者: Djamali Muhoza Paul D. Adams
• 机 构: DepartmentofChemistryandBiochemistry
• 出 处: 生物物理学期刊(英文)
• 发表日期: 2017年3期
• 关键词: Ras [Rat Sarcoma] Small MOLECULE Target CDC42 PROTEIN-PROTEIN Interactions Ras [

Cdc42 is a member of the Rho subfamily of Ras-related proteins, which were among the first oncogenic proteins to be identified as playing a sig-nificant role in a variety of cellular events [Barbacaid, 1987, Ann. Rev. Biochem]. Equally important, Protein-