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目的探讨丹参川芎嗪注射液治疗急性脑梗死的临床疗效。方法选取右江民族医学院附属医院2013年5月—2014年6月收治的急性脑梗死患者112例,按照随机数字表法分为对照组和观察组,各56例。两组患者均给予常规治疗,对照组给予复方丹参注射液治疗,观察组给予丹参川芎嗪注射液治疗。观察比较两组患者的临床疗效、治疗前后神经功能缺损评分、生活能力评分及血液流变学指标变化情况、不良反应发生情况。结果观察组治疗有效率为67.9%(38/56),高于对照组的48.2%(27/56),差异有统计学意义(P<0.05)。观察组神经功能缺损评分低于对照组,生活能力评分高于对照组,差异有统计学意义(P<0.05)。观察组全血黏度高切、全血黏度底低切、全血还原黏度、红细胞比容低于对照组,纤维蛋白原高于对照组,差异有统计学意义(P<0.05)。两组患者均无明显不良反应发生。结论丹参川芎嗪注射液治疗急性脑梗死的临床疗效良好,能够显著改善患者的神经功能缺损及血液流变学指标,提高患者的生活能力,安全性高。
Objective To investigate the clinical effect of ligustrazine injection on acute cerebral infarction. Methods 112 patients with acute cerebral infarction who were treated in Youjiang Medical College Affiliated Hospital from May 2013 to June 2014 were randomly divided into control group and observation group according to random number table method, 56 cases in each group. Both groups were given routine treatment, the control group given compound Danshen injection, the observation group was given Salvia Ligustrazine injection. The clinical curative effect, the neurological deficit score, the living ability score, the changes of hemorheology indexes and the adverse reactions before and after treatment were observed and compared between the two groups. Results The effective rate of treatment in observation group was 67.9% (38/56), which was higher than that in control group (48.2%, 27/56), the difference was statistically significant (P <0.05). The score of neurological deficit in the observation group was lower than that in the control group, and the score of life ability was higher in the observation group than in the control group (P <0.05). In the observation group, the whole blood viscosity was high, the whole blood viscosity was low, the whole blood viscosity was reduced, the hematocrit was lower than the control group, and the fibrinogen was higher than that in the control group. The difference was statistically significant (P <0.05). No significant adverse reactions occurred in both groups. Conclusion Salviae miltiorrhizae ligustrazine injection in the treatment of acute cerebral infarction with good clinical efficacy, can significantly improve the patient’s neurological deficit and hemorheological indicators, improve patients’ ability to live with high safety.