论文部分内容阅读
目的:研究危重病患者SIRS期肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）的水平与APACHE Ⅱ评分的相关性,并探讨其临床意义。方法:采用ELISA法检测30例危重病患者SIRS期TNF-α、IL-1β、IL-6水平,并进行APACHE Ⅱ评分。结果:30例患者血中TNF-α、IL-1β、IL-6水平均高于正常对照组（P<0.01）,与 APACHE Ⅱ评分呈正相关（P<0.05）。结论:同步检测细胞因子活性及进行 APACHE Ⅱ评分有助于危重病病情评估及预后判断。
Objective: To study the correlation between APACHE Ⅱ score and levels of TNF-α, IL-1β and IL-6 in SIRS of critical patients, And explore its clinical significance. Methods: The levels of TNF-α, IL-1β and IL-6 in SIRS of 30 critically ill patients were detected by ELISA. APACHE Ⅱ scores were also measured. Results: The blood levels of TNF-α, IL-1β and IL-6 in 30 patients were significantly higher than those in normal control group (P <0.01), and positively correlated with APACHE Ⅱ score (P <0.05). Conclusion: Simultaneous detection of cytokines activity and APACHE Ⅱ score contribute to the assessment of critical illness condition and prognosis.