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End stage renal disease (ESRD) and cardiovascular disease are induced by arteriosclerosis (AS). The latest investigation shows that AS is a special inflammatory state. The constant inflammation,which has been defined as a micro inflammatory state is related to the decline of renal function and blood purification, but not the result of infections caused by external pathogenic microorganisms or internal opportunistic pathogenic microorganisms. We investigated the mechanism of interleukin-10 (IL-10) gene-1082 A/G protection effect to keep ESRD patients away from micro inflammation and AS.