论文部分内容阅读
目的探讨蚕蛹蛋白对缺氧小鼠的抗疲劳作用,为其抗疲劳作用在高原的应用提供实验室依据。方法雄性昆明种小鼠80只(n=20),按体重随机分为4组,分别为缺氧对照组、蚕蛹蛋白低剂量组(0.5g/kg)、中剂量组(2.5g/kg)和高剂量组(5g/kg)。各组小鼠均在模拟5000m高原环境中饲养,连续灌胃10d后测小鼠力竭游泳时间、肝糖原含量、血乳酸及血糖水平。结果与缺氧对照组比较,蚕蛹蛋白显著延长了小鼠力竭游泳时间、增加肝糖原含量和降低血乳酸曲线下面积(P﹤0.01),其中以中剂量组效果最佳,而蚕蛹蛋白对血糖水平没有显著影响。结论蚕蛹蛋白对缺氧小鼠具有延缓疲劳产生和加速疲劳消除的作用。
Objective To investigate the anti-fatigue effect of silkworm pupa protein on hypoxic mice and provide a laboratory basis for the application of anti-fatigue effect on the plateau. Methods Eighty male Kunming mice (n = 20) were randomly divided into four groups according to body weight: hypoxia control group, low dose group (0.5g / kg) and medium dose group (2.5g / kg) And high dose group (5g / kg). The mice in each group were kept in the simulated 5000m plateau environment. The mice were subjected to exhaustive swimming time, hepatic glycogen content, blood lactate and blood glucose level after 10 days of continuous gavage. Results Compared with the hypoxia control group, the pupa protein significantly prolonged the exhaustive swimming time, increased hepatic glycogen content and decreased the area under the blood lactate curve (P <0.01), of which the middle dose group was the best, while the pupa protein No significant effect on blood glucose levels. Conclusions The pupa protein can delay the fatigue and accelerate the fatigue elimination in hypoxic mice.