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目的 :比较来氟米特和甲氨蝶呤治疗类风湿关节炎的疗效及安全性。方法 :80例类风湿关节炎病人、随机分配入 2组 ,各组 4 0例。 2组病人于试验前 1wk停用原有非甾体抗炎药 ,服用奥沙普秦(oxaprozin)每晚 2片。第 1组服抗炎 1号 ,每日 2片 ;抗炎 3号 ,每周 1次 ,每次 6片。第 2组服抗炎 2号 ,每日 2片 ;抗炎 4号每周 1次 ,每次 6片。 4～ 6wk后 2组停用奥沙普秦 ,其余服药至 2 4wk后揭盲。结果 :来氟米特组总有效率 93 % ,显效 85% ,甲氨蝶呤组分别为 93 %和 83 % ,P >0 .0 5。不良反应 :来氟米特组 9例占 2 3% ,甲氨蝶呤组 17例占4 3 %。结论 :来氟米特疗效与甲氨蝶呤相似 ,不良反应则较低
Objective: To compare the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis. Methods: Eighty patients with rheumatoid arthritis were randomized into two groups of 40 patients in each group. Two groups of patients discontinued the original non-steroidal anti-inflammatory drugs 1 week before the test, taking oxaprozin 2 tablets per night. Group 1 anti-inflammatory on the 1st, 2 tablets daily; anti-inflammatory 3, once a week, each 6. Group 2 anti-inflammatory on the 2nd, 2 tablets daily; anti-inflammatory 4 times a week, each 6. After 4 ~ 6wk 2 groups disabled oxaprozin, the rest of the medication to 24wk after the unblinded. Results: The total effective rate of leflunomide group was 93%, markedly effective 85%, methotrexate group were 93% and 83%, P> 0. Adverse reactions: leflunomide group 9 cases accounted for 23%, methotrexate group 17 cases accounted for 43%. Conclusion: The efficacy of leflunomide is similar to that of methotrexate with low adverse reactions