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作者们在14例成年普通感冒患者(男6例,女8例)所收集到的鼻分泌物,用细胞学检查发现有大量的颗粒白细胞,测定分泌物蛋白水解活性和各种血清蛋白酶抑制因子的浓度,有大量的蛋白酶溶酶体从细胞中析出进入鼻分泌物中。在感染期间粒性蛋白酶有很重要的作用,即噬菌作用和分解感染物质成为微小的分子并激活化学介质和酶原的作用。他们的蛋白水解活性是通过血清蛋白酶抑制因子或小分子量胰蛋白酶抑制因子的浸透作用而受到控制。弹性硬蛋白酶及溶解纤维蛋白的活性在感冒发作3天后增加。两者有显著性差异(P<0.01),提示在感冒期间有大量嗜中性弹性硬蛋白酶从粒性白细胞中释出并进入鼻分泌物中,而α_1-抗胰蛋白酶的漏入也随之增加。在大量鼻漏时,溶解纤维蛋白的高活性,主要归因于嗜中性蛋白酶,很适宜破坏和排除鼻分泌物。胰蛋白酶样蛋白酶活性非常低。在所有血清蛋白酶抑制因子中,未见到α-胰蛋白酶间抑制因子,仅在两例临床症状最严
The authors collected nasal secretions collected from 14 adult patients with common cold (6 males and 8 females) and found a large amount of granular leukocytes by cytology. The secretion proteolytic activity and various serum protease inhibitors The concentration of a large number of protease lysosomes from the cell into the nasal secretions. Granzyme plays an important role during infection, that is, phagocytosis and disintegration of infected substances into tiny molecules and activation of chemical mediators and zymogens. Their proteolytic activity is controlled by the saturation of serum protease inhibitors or small-molecule trypsin inhibitors. Elastin and fibrinolytic activity increased 3 days after onset of a cold. There was a significant difference between the two (P <0.01), suggesting that during the cold a large number of neutrophil elastase released from granulocytes and enter the nasal secretions, and α 1-antitrypsin leakage will follow increase. In a large number of rhinorrhea, the high activity of fibrinolytic dissolution, mainly due to neutrophilic protease, is very suitable to destroy and exclude nasal secretions. Trypsin-like protease activity is very low. Among all serum protease inhibitors, alpha-trypsin inhibitor was not seen, only two of the most clinically significant