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[目的]探讨血浆置换联合免疫抑制剂治疗血栓性血小板减少性紫癜(TTP)的临床疗效。[方法]对我院2005年4月~2010年4月期间收治的14例TTP患者进行血浆置换联合免疫抑制剂治疗,对疗效进行统计学分析。[结果]14例患者中,治愈8例,好转2例,无效4例。总有效率为71.4%。8例治愈患者随访6个月～1年,血小板(PLT)计数、乳酸脱氢酶(LDH)、肾功能、尿常规均正常。治疗过程中无不良反应发生。[结论]血浆置换联合免疫抑制剂是TTP的有效治疗方法。
[Objective] To investigate the clinical efficacy of plasma exchange combined with immunosuppressive agents in the treatment of thrombotic thrombocytopenic purpura (TTP). [Method] Totally 14 TTP patients admitted from April 2005 to April 2010 in our hospital were treated with plasma exchange and immunosuppressive agents, and the effects were statistically analyzed. [Result] Of the 14 patients, 8 were cured, 2 improved, and 4 were ineffective. The total effective rate was 71.4%. Eight cases of patients were followed up for 6 months to 1 year, platelet count (PLT), lactate dehydrogenase (LDH), renal function, urine were normal. No adverse reactions occurred during treatment. [Conclusion] Plasma exchange combined with immunosuppressive agents is an effective treatment for TTP.