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原发性肾病综合征(简称肾病)发病机制与机体免疫功能紊乱有关。吞噬细胞功能是反应机体免疫和防御机能的重要指标。我们采用鲁米诺生物化学发光技术,观察了62例肾病患儿外周血吞噬细胞化学发光(Phagocyte chemiluminescence,PCL)的动力学变化,同时,观测了不同临床时期肾病患儿血清肿瘤坏死因子(TNF)、血浆纤维结合蛋白(PFn)及临床免疫和生化指标变化,并与PCL进行了相关分析。现报告如下。 一、对象及方法 1.对象:肾病患儿62例,男46例,女16例,平均年龄6.5岁。诊断符合全国小儿肾脏协作组制定的诊断标准。分组:(1)极期组31例,初次发病,未用激素治疗。(2)未缓解组16例,接受常规激素治疗8周后,尿蛋白持续++以上。(3)缓解期组15例,接受激素治疗4～8周,尿蛋白阴转2周以上。(4)正常对照组16例,健康儿童,男10例,女6例,平均年龄6岁。
Primary nephrotic syndrome (referred to as nephropathy) pathogenesis and immune dysfunction. Phagocytic function is an important indicator of immune and defense functions. We used luminol bioluminescence technology to observe the kinetic changes of phagocyte chemiluminescence (PCL) in peripheral blood of 62 children with nephropathy. At the same time, we observed the changes of serum tumor necrosis factor (TNF) in children with different clinical stages of nephropathy ), Plasma fibronectin (PFn) and clinical immune and biochemical changes, and PCL were analyzed. The report is as follows. First, the object and method 1. Object: 62 cases of children with kidney disease, 46 males and 16 females, with an average age of 6.5 years. Diagnosis in line with the national pediatric kidney cooperation group to develop diagnostic criteria. Grouping: (1) 31 cases of the pole group, the initial onset, not with hormone therapy. (2) 16 cases did not relieve the group, accepted routine hormone therapy for 8 weeks, urinary protein continued more than ++. (3) 15 cases of remission group, received hormone therapy for 4 to 8 weeks, urinary protein overcast more than 2 weeks. (4) 16 cases of normal control group, healthy children, 10 males and 6 females, mean age 6 years old.