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LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer.However,the relationship between LGR6 expression in patients and clinicopathological factors remains unclear.This study aimed to clarify whether the expression level of LGR6 is correlated with colon adenocarcinoma progression.Immunohistochemistry was used to detect LGR6 expression in colon adenoma tissues (n =21),colon adenocarcinoma tissues (n =156),and adjacent normal tissues (n =124).The expression levels of LGR6 in colon adenoma and adenocarcinoma were significantly higher than those in normal colon epithelial tissues (P ＜ 0.001).Low LGR6 expression predicted a short overall survival in patients with colon adenocarcinoma (log-rank test,P =0.016).Univariate and multivariate survival analyses showed that,in addition to N and M classification,LGR6 expression served as an independent prognostic factor.Thus,low expression of LGR6 can be used as an independent prognostic parameter in patients with colon adenocarcinoma.